Publications

Peer-reviewed work and selected preprints

Areas of focus: islet biology and β-cell plasticity · type 2 diabetes and metabolic disease · inflammatory signaling and lipotoxicity · hepatic insulin signaling and zonation · stem-cell-derived pancreatic models.

Current lists are also maintained on PubMed and Google Scholar.

Peer-reviewed publications & preprints

  • The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways.

    Ayala I, et al., including Valdez IA.

    Nature Communications 16(1): 3408 (2025).

  • Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice.

    Valdez IA, et al.

    bioRxiv (2022). Preprint.

  • Insulin Resistance is Mechanistically Linked to Hepatic Mitochondrial Remodeling in NAFLD.

    Shannon CE, et al., including Valdez IA.

    Molecular Metabolism 45: 101154 (2021).

  • Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Clearance, and Sensitivity.

    Merovci A, et al., including Valdez IA.

    Diabetes 70(1): 204–213 (2021).

  • Dynamic Proteome Profiling of Human Pluripotent Stem Cell-Derived Pancreatic Progenitors.

    Loo LSW, et al., including Valdez IA.

    Stem Cells (2019).

  • Insulin Receptor-Mediated Signaling Regulates Pluripotency Markers and Lineage Differentiation.

    Gupta MK, et al., including Valdez IA.

    Molecular Metabolism 18: 153–163 (2018).

  • Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation.

    Valdez IA, et al.

    Cell Reports 15(3): 460–470 (2016).

  • Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.

    Teo AK, et al., including Valdez IA.

    Stem Cell Reports 6(3): 357–367 (2016).

  • Cellular Stress Drives Pancreatic Plasticity.

    Valdez IA, et al.

    Science Translational Medicine 7(273): 273ps2 (2015).

  • Preserved DNA Damage Checkpoint Pathway Protects Against Complications in Long-Standing Type 1 Diabetes.

    Bhatt S, et al., including Valdez IA.

    Cell Metabolism 22(2): 239–252 (2015).

  • Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling.

    Teo AK, et al., including Valdez IA.

    Stem Cell Reports 3(1): 5–14 (2014).

For a more detailed academic record, including conference presentations and grants, see my CV.